At our institute we combine structural biology (mainly X-ray crystallography), biophysical approaches, and biochemistry with cell biology to allow for an integrated research approach.

Research topics focus on RNA-based gene regulation in eukaryotes (Niessing), structure-guided inhibitor design (Niessing), and various areas of biotechnology, including biomaterials for medical applications and recombinant biosurfactants for a growing bioeconomy (Rosenau). For more details, please visit the groups subpages under the INSTITUTE/RESEARCH pulldown menue.

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Master or PhD students, please don't hesitate to contact us directly.

 

News

Proske, M., Janowski, R., Bacher, S., Kang, H.-S., Monecke, T., Koehler, T., Hutten, S., Tretter, J., Crois, A., Molitor, L., Varela-Rial, A., Fino, R., Donati, E., de Fabritiis, G., Dormann, D., Sattler, M., & Niessing, D. (2024). PURA syndrome-causing mutations impair PUR-domain integrity and affect P-body association. 
ELife, 13. https://doi.org/10.7554/ELIFE.93561

Kissmann, A.K., Bolotnikov, G., Li, R., Müller, F., Xing, H., Krämer,·M., Gottschalk, K.-E., Andersson, J., Weil, T., Rosenau, F. (2024). IMPATIENT‑qPCR: monitoring SELEX success during in vitro aptamer evolution.
Applied Microbiology and Biotechnology  108:284. https://doi.org/10.1007/s00253-024-13085-7

Zhang, Y., Xing, H., Bolotnikov, G., Krämer, M., Bozdogan, A., Kissmann, A.K., Weil, T., Spellerberg, B., Stenger, S., Rosenau, F. (2024). Robust Fluorometric Aptamer Assay for Direct and Rapid Detection of Clinical Isolates of Candida spec. 
Int. J. Mol. Sci. 2024, 25, 3444. Doi: 10.3390/ijms25063444

Witzenberger, M., Burczyk, S., Settele, D., Mayer, W., Welp, L.M., Heiss, M., Wagner, M., Monecke, T., Janowski, R., Carell, T., Urlaub, H., Hauck, S.M., Voigt, A.* and Niessing, D.* (2023).
Human TRMT2A methylates tRNA and contributes to translation fidelity.
Nucleic Acids Res. Jul 3;gkad565. Online ahead of print. 
https://doi.org/10.1093/nar/gkad565

Lena Molitor*, Melina Klostermann*, Sabrina Bacher, Juliane Merl-Pham, Nadine Spranger, Sandra Burczyk, Carolin Ketteler, Ejona Rusha, Daniel Tews, Anna Pertek, Marcel Proske, Anke Busch, Sarah Reschke, Regina Feederle, Stefanie M Hauck, Helmut Blum, Micha Drukker, Pamela Fischer-Posovszky, Julian König, Kathi Zarnack^#, Dierk Niessing^#.
Nucleic Acids Research (2023). https://doi.org/10.1093/nar/gkac1237